Lactobacilli are essential for keeping the vaginal flora healthy and for the prevention of vaginal infections. Under certain circumstances, lactobacilli may be lost and vaginal infection may occur with accompanying symptoms such as vaginal discharge, itching, and burning pain. We know today that the intestinal tract functions as a reservoir for vaginal lactobacilli, and that oral supplementation of lactobacilli helps to keep the vaginal flora normal and to prevent vaginal infection. It is further known that the vaginal flora is kept healthy with a physiologic composition of lactobacilli. Therefore, a composition of the physiological vaginal lactobacilli has been developed to support the vaginal flora with lactobacilli using oral supplementation. This oral supplementation with lactobacilli results in a physiologic maintenance of the vaginal flora and in vaginal health. Astarte oral supplementation with lactobacilli can either prevent vaginal infection or restore the vaginal flora after vaginal infection.
• Lactobacillus crispatus LBV 88
• Lactobacillus rhamnosus LBV 96
• Lactobacillus jensenii LBV 116
• Lactobacillus gasseri LBV 150
ASTARTE obtain the European and US patent (EP 2509 610; US 8846 027) and is deposited for further fillings in several countries.
Data of a study with women (bacterial vaginosis):
Lactobacilli orally administered, vaginal sample before, one week after oral daily intake and third vaginal sample after one week without probiotic treatment to see long term effect.
The over all median concentration of Lactobacilli: at the beginning of study, the levels were low (median 3,07E+06; SD+/- 5,23E+07); after oral intake concentration increased (median 5,77E+07; SD 1,72E08); after a one week, dose-free interval, levels were higher than before therapy (median 2,71E+07).
The change in Nugent score and the change from bacterial vaginosis to an intermediate vaginal flora: Median Nugent score before probiotic administration was 8 (SD 1,07) which means a grade 3 of the vaginal flora (bacterial vaginosis in clinical terms). After one week, improvement of the Nugent scores to score 6 (SD 0,79) which means grade 2, intermediate flora, no more bacterial vaginosis. After one more week this clinical microbiological diagnosis was unchanged, Nugent score 6 (SD 1,79), grade 2 (SD 0,55).
Only after one week of oral consumption the number of lactobacilli colonies in the vaginal flora significantly increases.
NUGENT SCORE AND GRADING OF VAGINAL SWABS
See how we selected our Astarte strains before isolation and cultivation.
European Journal of Obstetrics & Gynecology and Reproductive Biology
Strategies for the evaluation and selection of potential vaginal probiotics from human sources
Role of microbiota correction in complex treatment of pregnant women with herpesvirus infection
Influence of Orally Administered Probiotic Lactobacillus Strains on Vaginal Microbiota in Women with Breast Cancer during Chemotherapy
Effect of a yoghurt drink containing Lactobacillus strains on bacterial vaginosis in women
Bacterial vaginosis is a mismatch of the vaginal flora. Normally in healthy women the vaginal flora is dominated by lactobacillus. There are many different lactobacilli species responsible for mantaining a healthy environment in the vagina. If lactobacilli disappear there is an overgrowth of mostly anaerobic bacteria like Gardnerella, Prevotella, Mobiluncus which cause a vaginal discharge and bad odor or sometimes also vaginal and/or lower abdominal pain.
Bacterial vaginosis is not a sexually transmitted disease. It is caused though a complete loss of lactobacilli, which are responsible for a normal, healthy vaginal environment.
Due to new data of scientific research we know today, that the intestinal tract is a reservoir for lactobacilli. From studies we know that lactobacilli colonize the intestinal tract. Especially the rectum and anus are colonized by lactobacilli as well as the vagina. If there is a lactobacillus loss in the intestinal tract then there is a high risk for bacterial vaginosis. Loss of lactobacilli in the rectum are associated with frequently recurrent bacterial vaginosis.
There is the possibility to support the vagina with lactobacilli either locally or orally. New scientific data shows that the vaginal lactobacillus flora vagina can be enriched with lactobacilli.
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HSO Holding GmbH
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FAX: +43-1-235 07 90
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HSO Health Care GmbH
A-1010 Vienna, Austria
TEL: +43 (0) 1 235 07 80
FAX: +43 (0) 1 235 07 90
FN 30786k, Handelsgericht Wien
VAT-ID: ATU 15313701
The object of the company is the exercise of the profession of research & development, especially through containing the company HSO Health Care GmbH (FN 353912 i), including necessary assistance.
Managing director: Helmut Essl