CLINICAL STUDY ON CHANGING VAGINAL FLORA AFTER ORAL PROBIOTIC INTAKE

Data of a study with women (bacterial vaginosis):
Lactobacilli orally administered, vaginal sample before, one week after oral daily intake and third vaginal sample after one week without probiotic treatment to see long term effect.

The over all median concentration of Lactobacilli: at the beginning of study, the levels were low (median 3,07E+06; SD+/- 5,23E+07); after oral intake concentration increased (median 5,77E+07; SD 1,72E08); after a one week, dose-free interval, levels were higher than before therapy (median 2,71E+07).

The change in Nugent score and the change from bacterial vaginosis to an intermediate vaginal flora: Median Nugent score before probiotic administration was 8 (SD 1,07) which means a grade 3 of the vaginal flora (bacterial vaginosis in clinical terms). After one week, improvement of the Nugent scores to score 6 (SD 0,79) which means grade 2, intermediate flora, no more bacterial vaginosis. After one more week this clinical microbiological diagnosis was unchanged, Nugent score 6 (SD 1,79), grade 2 (SD 0,55).

Only after one week of oral consumption the number of lactobacilli colonies in the vaginal flora significantly increases.

NUGENT SCORE AND GRADING OF VAGINAL SWABS

  • Bacterial vaginosis (BV) changed and continued into intermediate flora (Nugent 8 to Nugent 6) microbiologic diagnosis 
  • Grading the vaginal flora Grade 3 (BV) to Grade 2 (intermediate Flora, no infection) 
  • Women self-observation described a much better feeling, no discharge, no odor

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